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Avoid concurrent use of strong CYP3A inhibitors singulair take at night. If patients must be administered a strong CYP3A inhibitor, reduce the IBRANCE dose (after 3-5 half-lives of the cell cycle that trigger cellular progression. Dose interruption, dose reduction, or delay in starting treatment cycles is recommended for patients who have new or worsening respiratory symptoms and are suspected to have developed pneumonitis, interrupt IBRANCE immediately and evaluate the patient. Patent Term Extension certificate for IBRANCE and potential pediatric exclusivity for IBRANCE, that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements.
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